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- Title
Effective treatment of post-spinal fusion methicillin-resistant Staphylococcus aureus vertebral osteomyelitis with linezolid in a renal-transplant patient.
- Authors
Yunde, Atsushi; Inage, Kazuhide; Orita, Sumihisa; Yamauchi, Kazuyo; Suzuki, Miyako; Sakuma, Yoshihiro; Kubota, Go; Oikawa, Yasuhiro; Sainoh, Takeshi; Sato, Jun; Fujimoto, Kazuki; Shiga, Yasuhiro; Abe, Koki; Kanamoto, Hirohito; Suzuki, Takane; Takahashi, Kazuhisa; Ohtori, Seiji
- Abstract
Background: Methicillin-resistant Staphylococcus aureus (MRSA)-caused pyogenic spondylitis is a serious complication associated with lumbar fusion surgery. Often, anti-MRSA drugs are not used properly or patients discontinue drug use because of side effects including renal failure. Case presentation: We report a case at our hospital of a 54-year-old male renal-transplant patient who developed MRSA vertebral osteomyelitis after spinal fusion and was treated effectively with linezolid. After diagnosis of post- fusion surgery osteomyelitis, we conducted emergency flushing and debridement and began linezolid treatment (1200 mg/day, divided) immediately after the surgery. The level of C-reactive protein gradually decreased and became negative 4 weeks after the initiation of linezolid treatment. Serum creatinine level was approximately 1.3 mg/dL throughout the treatment period, indicating no deterioration in renal function. Conclusion: These results suggest that early flushing and debridement together with linezolid administration is an effective treatment for MRSA vertebral osteomyelitis in renal-transplant patients.
- Subjects
OSTEOMYELITIS treatment; STAPHYLOCOCCUS aureus infections; LINEZOLID; LUMBAR vertebrae surgery; SURGICAL complications; THERAPEUTICS
- Publication
BMC Research Notes, 2015, Vol 8, p1
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-015-1694-7