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- Title
CRYSTAL STRUCTURE OF THE COBALT HUMAN INSULIN DERIVATIVE.
- Authors
Prugovečki, Biserka; Ivetić, Natalija; Matković-Čalogović, Dubravka
- Abstract
The structure of the human cobalt insulin derivative at 1.73 Å resolution is described. Single crystals were prepared by the hanging drop vapour diffusion crystallization method using Zn-free insulin and cobalt(II) acetate. The crystal structure was determined by the single crystal X-ray diffraction method. The investigated insulin derivative exhibits the T6 form of insulin and crystallizes in the trigonal system in space group R3, with the unit cell parameters a = b = 81.43 Å and c = 33.75 Å. There are two cobalt atoms per insulin hexamer which are octahedrally coordinated by three symmetry-related Nε2 atoms of three HisB10/HisD10 and three oxygen atoms from three water molecules.
- Subjects
CRYSTAL structure; COBALT compounds; INSULIN derivatives; CRYSTALLIZATION; X-ray diffraction; SINGLE crystals
- Publication
Macedonian Journal of Chemistry & Chemical Engineering, 2015, Vol 34, Issue 1, p1
- ISSN
1857-5552
- Publication type
Article