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- Title
Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4.
- Authors
Elmowafy, Ahmed Yahia; El Maghrabi, Hanzada Mohamed; Zahab, Mohamed Ahmed; Elwasif, Salwa Mahmoud; Bakr, Mohamed Adel
- Abstract
Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Treatment with interferon plus ribavirin, steroid, and cyclophosphamide was tried but failed. After introduction of a sofosbuvir-based regimen to the treatment, sustained virologic response was achieved and nephrotic syndrome remission was induced successfully. We could conclude that HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia could be treated successfully with immunosuppressive drugs plus sofosbuvir and dacalatasvir.
- Subjects
GLOMERULONEPHRITIS; CRYOGLOBULINEMIA; SOFOSBUVIR; HEPATITIS C treatment; HEPATITIS C virus; ANTIVIRAL agents; NEPHROTIC syndrome; IMMUNOSUPPRESSIVE agents
- Publication
Iranian Journal of Kidney Diseases, 2018, Vol 12, Issue 6, p382
- ISSN
1735-8582
- Publication type
journal article