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- Title
Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results.
- Authors
Ghosh–Laskar, Sarbani; Yathiraj, Prahlad H.; Dutta, Debnarayana; Rangarajan, Venkatesh; Purandare, Nilendu; Gupta, Tejpal; Budrukkar, Ashwini; Murthy, Vedang; Kannan, Sadhana; Agarwal, Jai Prakash
- Abstract
Background Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically. Methods Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter. Results Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p = .024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50% vs 21%; p = .038). Disease-related outcomes between arms (median follow-up, 70 months) were similar. Conclusion IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1481-E1487, 2016
- Subjects
HEAD &; neck cancer treatment; CANCER treatment; SQUAMOUS cell carcinoma; INTENSITY modulated radiotherapy; CANCER radiotherapy research; XEROSTOMIA
- Publication
Head & Neck, 2016, Vol 38, pE1481
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24263