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- Title
FDG‐PET‐CT/MRI in head and neck squamous cell carcinoma: Impact on pretherapeutic N classification, detection of distant metastases, and second primary tumors.
- Authors
Stadler, Thomas M.; Morand, Grégoire B.; Rupp, Niels J.; Hüllner, Martin W.; Broglie, Martina A.
- Abstract
Background: To assess the effect of 18‐fluorodeoxyglucose positron emission tomography (FDG‐PET) in the pretherapeutic staging of N classification, detection rate of distant metastases, and second primaries. Methods: Retrospective study on patients with head and neck carcinoma. We compared pretherapeutic N classification by ultrasound, computed tomography (CT)/magnetic resonance imaging (MRI), and FDG‐PET‐CT/MRI. Results: A change in the N classification due to FDG‐PET‐CT/MRI was observed in 116 patients (39.5%) compared to N classification by ultrasound and fine‐needle aspiration cytology. Patients with advanced nodal classification (>N2a) were more likely to be reclassified. Distant metastases were detected in 19 patients and a total of 36 second primaries were diagnosed by FDG‐PET‐CT/MRI. Detection of distant metastases was more likely in regional advanced disease (>N2a). Smokers (>10 py) had a significantly higher risk of second primary. Conclusion: FDG‐PET‐CT/MRI leads to a significant change in pretherapeutic N classification. The cumulative incidence of distant metastases and second primaries was 18.7%.
- Subjects
SECONDARY primary cancer; SQUAMOUS cell carcinoma; HEAD &; neck cancer; POSITRON emission tomography; METASTASIS; ULTRASONIC imaging
- Publication
Head & Neck, 2021, Vol 43, Issue 7, p2058
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26668