We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Identification of upregulated genes in oral squamous cell carcinomas.
- Authors
Lessa, Roberta C.; Campos, Antonio Hugo J. F. M.; de Freitas, Carlos Elias; da Silva, Felipe Rodrigues; Kowalski, Luiz Paulo; Carvalho, André Lopes; Vettore, André Luiz
- Abstract
Background Oral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors. Methods To identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription-polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples. Results and Conclusions The ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them ( ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1475-1481, 2013
- Subjects
SQUAMOUS cell carcinoma; TUMORS; ONCOLOGY; POLYMERASE chain reaction; METASTASIS; GENES
- Publication
Head & Neck, 2013, Vol 35, Issue 10, p1475
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23169