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- Title
Prognostic value of <sup>18</sup>F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: Comparisons of volume-based metabolic parameters.
- Authors
Moon, Seung Hwan; Choi, Joon Young; Lee, Hwan Joo; Son, Young‐Ik; Baek, Chung‐Hwan; Ahn, Yong Chan; Park, Keunchil; Lee, Kyung‐Han; Kim, Byung‐Tae
- Abstract
Background The prognostic significance of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil. Methods We enrolled a total of 69 patients with SCC of the tonsil who underwent pretreatment 18F-FDG PET/CT. We measured maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and asymmetry indices (of SUVmax, MTV, and TLG). The prognostic significance of these parameters and clinical variables was assessed by Cox proportional hazards regression analysis. Results Multivariate analyses with adjustments for age, sex, and American Joint Committee on Cancer stage showed that only TLG (hazard ratio = 1.020, 95% confidence interval 1.003-1.037, p = .023) was an independent predictive factor associated with decreased overall survival. Conclusion TLG is a significant independent metabolic prognostic factor for overall survival in patients with SCC of the tonsil. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
- Subjects
PROGNOSTIC tests; SQUAMOUS cell carcinoma; TONSIL cancer; TUMOR classification; GLYCOLYSIS; STATISTICAL correlation
- Publication
Head & Neck, 2013, Vol 35, Issue 1, p15
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.22904