We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Greater Curvature Plication with Duodenal-Jejunal Bypass: a Novel Metabolic Surgery for Type 2 Diabetes Mellitus.
- Authors
Liu, Qing; Wang, Ling-Di; Qiu, Nian-Cun; Cen, Xiao-Xia; Zha, Si-Luo; Shan, Cheng-Xiang; Zhang, Wei; Qiu, Ming; Liu, Miao-E; Wang, Yang
- Abstract
Objective: The study investigated the use of great curvature plication with duodenal-jejunal bypass (GCP-DJB) in a type 2 diabetic with obesity rat model.Methods: Twenty-two Sprague-Dawley rats were given a high fat and sugar diet with subsequent intraperitoneal injection of a small dosage of streptozotocin (30 mg/kg) and randomly assigned to either GCP-DJB (n = 12) or Sham surgery (n = 10). Body weight, peripheral blood glucose, and fasting serum insulin were assayed, and insulin resistance index (IRI) was calculated, before and at 1, 2, 4, and 8 weeks after surgery.Results: No differences were found in the preoperative characteristics of the two groups (P > 0.05). At week 1, the body weights decreased significantly, but there was no significant difference between the two groups (P > 0.05).The fasting blood glucose was significantly lower in the GCP-DJB than in the Sham group (P < 0.05), serum insulin levels were higher (P < 0.05), and IRI began to decline (P < 0.05). From 2 to 8 weeks, the body weight of Sham group gradually recovered and continued to rise, while the GCP-DJB group remained at a relatively lower state. Compared to the Sham group, the body weight, fasting blood glucose as well as IRI of GCP-DJB rats had significantly decreased (P < 0.05). But, the fasting insulin concentrations had significantly increased (P < 0.05).Conclusion: This novel GCP-DJB procedure established a stable animal model for the study of metabolic surgery to treat type 2 diabetes mellitus (T2DM).
- Subjects
JEJUNOILEAL bypass; TYPE 2 diabetes; ANIMAL models of diabetes; DUODENUM surgery; OBESITY in animals; LABORATORY rats; WEIGHT loss; BLOOD sugar measurement
- Publication
Obesity Surgery, 2018, Vol 28, Issue 6, p1595
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-017-3057-z