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- Title
The Contributing Role of Bile Acids to Metabolic Improvements After Obesity and Metabolic Surgery.
- Authors
Fouladi, Farnaz; Mitchell, James; Wonderlich, Joseph A.; Steffen, Kristine
- Abstract
Obesity and metabolic surgery (OMS) leads to several metabolic improvements, which often occur prior to substantial weight loss. Therefore, other factors in addition to weight loss contribute to the metabolic benefits. This literature review offers an overview of studies investigating bile acids (BAs) and their metabolic effects after OMS. Rearrangement of enterohepatic circulation, changes in BA synthesis, BA conjugation, intestinal reabsorption, and alterations in the gut microbiota are potential mechanisms for altered BA profiles after surgery. Increased BA levels are associated with improved glucose homeostasis and lipid profiles, which are mediated by two major receptors: the Transmembrane G-protein Coupled Receptor and the Farnesoid X Receptor. Therefore, pharmacological manipulation of BAs and their receptors may be viable targets for less invasive obesity treatment.
- Subjects
BILE acids; BARIATRIC surgery; METABOLIC disorder treatment; WEIGHT loss; ENTEROHEPATIC circulation; PHARMACOLOGY
- Publication
Obesity Surgery, 2016, Vol 26, Issue 10, p2492
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-016-2272-3