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- Title
Low-dose lipopolysaccharide protects nerve cells against spinal cord injury via regulating the PI3K–AKT–Nrf2 signaling pathway.
- Authors
Li, Wei-Chao; Yao, Shao-Ping; Zhang, Jun; Liu, Wei-Bing; Liu, Jie; Geng, Cheng-Kui
- Abstract
The article presents Low-dose lipopolysaccharide protects nerve cells against spinal cord injury via regulating the PI3K–AKT–Nrf2 signaling pathway. Topics discussed include this study explored the molecular mechanism behind the protective effects from low-dose lipopolysaccharide (LPS) on an in-vitro model of spinal cord injury (SCI); and PC12 cells were treated with different concentrations of LPS and the cell counting kit-8 assay was used to measure the toxicity of LPS to the cells.
- Subjects
CELLULAR signal transduction; SPINAL cord injuries; NEURONS; LIPOPOLYSACCHARIDES; BACTERIAL cell walls; MICROGLIA; REPERFUSION
- Publication
Biochemistry & Cell Biology, 2021, Vol 99, Issue 5, p527
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/bcb-2020-0641