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- Title
The Effects of Bumetanide on Human Umbilical Artery Contractions.
- Authors
Dayioglu, Emel; Buharalioglu, C. Kemal; Saracoglu, Ferit; Akar, Fatma
- Abstract
The authors investigate the effect of bumetanide, an inhibitor of NKCC1 and a loop diuretic, on the tone of human umbilical artery (HUA). Rings of HUA (n = 35) from vaginal deliveries were suspended for isometric tension recordings in organ baths. Cumulative concentration-response curves to serotonin, histamine, and KCl were performed in the absence (control) or in the presence of bumetanide. The relaxant effect of bumetanide was also evaluated in serotonin- and histamine-induced contractions. Bumetanide inhibited HUA tone in serotonin- and histamine-induced contractions with significant changes in the potency (pD2) and maximum contractile response (Emax) values. However, only pD2 values for KCl-induced contraction significantly changed in the presence of bumetanide. Bumetanide caused concentration-dependent and sustained relaxations in serotonin-induced contraction; however, there was refractoriness in histamine-induced contraction. These findings raise the possibility that NKCC1 may play a role in the regulation of the umbilical artery tone.
- Subjects
BUMETANIDE; DIURETICS; UMBILICAL cord; SEROTONIN; HISTAMINE
- Publication
Reproductive Sciences, 2007, Vol 14, Issue 3, p246
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1177/1933719107300871