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- Title
Adenosine A<sub>3</sub> receptors regulate heart rate, motor activity and body temperature.
- Authors
Yang, J. N.; Wang, Y.; Garcia-Roves, P. M.; Björnholm, M.; Fredholm, B. B.
- Abstract
Aim: To examine the phenotype of mice that lack the adenosine A3 receptor (A3R). Methods: We examined the heart rate, body temperature and locomotion continuously by telemetry over several days. In addition, the effect of the adenosine analogue R- N6-phenylisopropyl-adenosine (R-PIA) was examined. We also examined heat production and food intake. Results: We found that the marked diurnal variation in activity, heart rate and body temperature, with markedly higher values at night than during day time, was reduced in the A3R knock-out mice. Surprisingly, the reduction in heart rate, activity and body temperature seen after injection of R-PIA in wild type mice was virtually eliminated in the A3R knock-out mice. The marked reduction in activity was associated with a decreased heat production, as expected. However, the A3R knock-out mice, surprisingly, had a higher food intake but no difference in body weight compared to wild type mice. Conclusions: The mice lacking adenosine A3 receptors exhibit a surprisingly clear phenotype with changes in diurnal rhythm and temperature regulation. Whether these effects are due to a physiological role of A3 receptors in these processes or whether they represent a role in development remains to be elucidated.
- Subjects
ADENOSINES; MICE; PHENOTYPES; BIOTELEMETRY; HEART beat; CIRCADIAN rhythms
- Publication
Acta Physiologica, 2010, Vol 199, Issue 2, p221
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/j.1748-1716.2010.02091.x