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- Title
Prognosis of Patients with Arteriosclerosis Obliterans Treated with LDL-Apheresis.
- Authors
Agishi, Tetsuzo; Nakasato, Satoshi; Ota, Kazuo
- Abstract
A total of 55 arteriosclerosis obliterans (ASO) patients with hypercholesterolemia (total cholesterol [TC] ≥ 220 mg/dL or low density lipoprotein cholesterol [LDL-C] ≥ 140 mg/dL) were treated with LDL-apheresis. A follow-up questionnaire was sent to 39 of these patients by mail. Reported herein are effects of the LDL-apheresis and prognosis in 26 patients (17 men and 9 women) who undertook the LDL-apheresis and responded to the follow-up questionnaire. The subjective symptoms reported were investigated at three stages: before the treatment, immediately after the final LDL-apheresis, and at the follow-up observation time (March, 1993). An LDL-cholesterol level was reduced from 171 ± 30 (mean ± SD) to 83 ± 39 mg/dL by 10 ± 3 applications of the apheresis. No aggravation in clinical symptoms was observed in any patient. Improvement rates of the clinical symptoms immediately after the final LDL-apheresis in these particular patients were as follows: foot chillness 52%, foot numbness 58%, foot dullness 81%, intermittent claudieation 62%, foot pain at rest 75%, and ulcer at toes 100%. According to analysis of the questionnaire, these improvements in the clinical symptoms have been maintained at relatively high rates such as 69% in foot chillness, 91% in foot numbness, 100% in foot dullness, 81% in intermittent claudieation, 89% in foot pain at rest, and 100% in ulcer at toes for 1.2 ± 0.8 (0.1 to 2.4) years of the observation period. The improvements are suggested to be due to the amelioration in peripheral blood flow as evidenced by development of new collaterals observed on arteriograms.
- Subjects
ARTERIOSCLEROSIS obliterans; HYPERCHOLESTEREMIA; HEMAPHERESIS; FOOT diseases; BLOOD flow; PATIENTS
- Publication
Vascular Surgery, 1994, Vol 28, Issue 8, p513
- ISSN
0042-2835
- Publication type
Article
- DOI
10.1177/153857449402800802