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- Title
Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica.
- Authors
Oyadomari, Yasumoto; Goto, Yasuyuki; Suganuma, Keisuke; Kawazu, Shin-ichiro; Becking, Leontine E.; Fusetani, Nobuhiro; Nakao, Yoichi
- Abstract
A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.
- Subjects
JAPAN; TETRAMIC acids; SPONGES (Invertebrates); MARINE natural products; GLYCOSIDES; NUCLEAR magnetic resonance
- Publication
Marine Drugs, 2024, Vol 22, Issue 4, p171
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22040171