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- Title
Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications.
- Authors
Fernández, Sergio; Arnáiz, Virginia; Rufo, Daniel; Arroyo, Yolanda
- Abstract
Indole is a versatile pharmacophore widely distributed in bioactive natural products. This privileged scaffold has been found in a variety of molecules isolated from marine organisms such as algae and sponges. Among these, indole alkaloids represent one of the biggest, most promising family of compounds, having shown a wide range of pharmacological properties including anti-inflammatory, antiviral, and anticancer activities. The aim of this review is to show the current scenario of marine indole alkaloid derivatives, covering not only the most common chemical structures but also their promising therapeutic applications as well as the new general synthetic routes developed during the last years.
- Subjects
MARINE natural products; SYNTHETIC products; INDOLE alkaloids; NATURAL products; MARINE algae; INDOLE; ALKALOIDS
- Publication
Marine Drugs, 2024, Vol 22, Issue 3, p126
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22030126