We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficiency of the interfacial charge transfer complex between TiO<sub>2</sub> nanoparticles and caffeic acid against DNA damage in vitro: A combinatorial analysis.
- Authors
LAZIĆ, VESNA; VUKOJE, IVANA; MILIĆEVIĆ, BOJANA; SPREMO-POTPAREVIĆ, BILJANA; ŽIVKOVIĆ, LADA; TOPALOVIĆ, DIJANA; BAJIĆ, VLADAN; SREDOJEVIĆ, DUŠAN; NEDELJKOVIĆ, JOVAN M.
- Abstract
The genotoxic and antigenotoxic behavior of the interfacial charge transfer (ICT) complex between nano-sized TiO2 particles and caffeic acid (CA) was studied in in vitro experiments. The formation of the ICT complex is indicated by the appearance of absorption in visible-spectral range. The continual variations method indicated bridging coordination between the ligand, caffeic acid, and the surface Ti atoms, while the stability constant of the ICT complex was found to be 1.5×103 mol-1 L. An agreement between the experimental data and the theoretical results, based on the density functional theory, was found. The ICT complex and its components did not display genotoxicity in the broad concentration range 0.4‒8.0 mg mL-1 TiO2 at a mole ratio c(TiO2)/c(CA) = 8. On the other hand, post-treatment of damaged DNA by the ICT complex induced antigenotoxic effect at lower concentrations, but at higher concentrations, 5.125- -10.250 mg mL-1 ICT, the ICT complex did not show any beneficial effect on H2O2-induced DNA damaged cells. The experimental data were analyzed using the combinatorial method to determine the effect of component interaction on the genotoxic and antigenotoxic behavior of the ICT complex.
- Subjects
ELECTRON donor-acceptor complexes; COMBINATORICS; DNA damage; STABILITY constants; CAFFEIC acid; DENSITY functional theory
- Publication
Journal of the Serbian Chemical Society, 2019, Vol 84, Issue 6, p539
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC181217017L