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- Title
Intramuscular dissociation of echogenicity in the triceps surae characterizes sporadic inclusion body myositis.
- Authors
Nodera, H.; Takamatsu, N.; Matsui, N.; Mori, A.; Terasawa, Y.; Shimatani, Y.; Osaki, Y.; Maruyama, K.; Izumi, Y.; Kaji, R.
- Abstract
Background and purpose Differential diagnosis of sporadic inclusion body myositis (s- IBM) and polymyositis ( PM)/dermatomyositis ( DM) is difficult and can affect proper disease management. Detection of heterogeneous muscular involvement in s- IBM by muscle sonography could be a unique diagnostic feature. Methods Sonography of the lower leg and forearm was performed in patients with s- IBM, PM/ DM and control subjects ( n = 11 each). Echo intensities ( EIs) of the adjacent muscles [medial head of the gastrocnemius versus soleus and the flexor digitorum profundus ( FDP) versus flexor carpi ulnaris ( FCU)] were scored by three blinded raters. The mean EIs of these muscles were compared using computer-assisted histogram analysis. Results Both evaluation methods showed high echoic signals in the gastrocnemius of patients with s- IBM. EIs were significantly different between the gastrocnemius and soleus in patients with s- IBM, but not in those with DM/ PM and the controls. In the forearm, although the EI of the FDP was higher in the s- IBM group than in the other groups, the EI differences between the FDP and FCU did not differ significantly between disease groups. The difference in area under the curves to differentiate between s- IBM and DM/ PM was greatest between the gastrocnemius−soleus EIs (0.843; P = 0.006). Conclusions High echoic signals in the medial gastrocnemius compared with those of the soleus are suggestive of s- IBM over PM/ DM.
- Subjects
HISTOGRAMS; INCLUSION body myositis; MYOSITIS; ULTRASONIC imaging; ACHILLES reflex
- Publication
European Journal of Neurology, 2016, Vol 23, Issue 3, p588
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/ene.12899