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- Title
Multi-omics analysis reveals genes and metabolites involved in Streptococcus suis biofilm formation.
- Authors
Wang, Haikun; Fan, Qingying; Wang, Yuxin; Yi, Li; Wang, Yang
- Abstract
Background: Streptococcus suis is an important zoonotic pathogen. Biofilm formation largely explains the difficulty in preventing and controlling S. suis. However, little is known about the molecular mechanism of S. suis biofilm formation. Results: In this study, transcriptomic and metabolomic analyses of S. suis in biofilm and planktonic states were performed to identify key genes and metabolites involved in biofilm formation. A total of 789 differential genes and 365 differential metabolites were identified. By integrating transcriptomics and metabolomics, five main metabolic pathways were identified, including amino acid pathway, nucleotide metabolism pathway, carbon metabolism pathway, vitamin and cofactor metabolism pathway, and aminoacyl-tRNA biosynthesis metabolic pathway. Conclusions: These results provide new insights for exploring the molecular mechanism of S. suis biofilm formation.
- Subjects
STREPTOCOCCUS suis; CARBON metabolism; TRANSCRIPTOMES; MULTIOMICS; AMINOACYL-tRNA
- Publication
BMC Microbiology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2180
- Publication type
Article
- DOI
10.1186/s12866-024-03448-5