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- Title
Selective adsorption and identification of penicillin G sodium in milk by molecularly imprinted polymer doped carbon dot.
- Authors
Xu, Yi; Wang, Haiping; Bai, Qingyan; Ma, Shujuan; Bo, Chunmiao; Ou, Junjie
- Abstract
A carbon dot (CD) was prepared by o-phenylenediamine and water, which showed bright yellow fluorescence under ultraviolet light irradiation (λ = 580 nm), and verified good fluorescence quenching effect on penicillin G sodium (Png-Na). Using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a crosslinker, and Png-Na as a template, a kind of composite microsphere combining CD and molecularly imprinted polymer (MIP) was synthesized by surface-initiated atomic transfer radical polymerization (SI-ATRP). For reasons of comparison, we also prepared MIP without CD and non-imprinted polymers (NIPs). Through static and dynamic adsorption experiments, the maximum adsorption capacity was 47.05 mg g−1 and the equilibrium time was 30 min. High-performance liquid chromatography (HPLC) was utilized to determine the content of Png-Na in the spiked milk samples. A sensitive, rapid, and simple method for determination of Png-Na in food samples was developed. The utilized approach enabled the quantification of Png-Na within the concentration range 20–1000 μg L−1 (with a limit of detection of 5 μg L−1). The recoveries achieved were in the range 93.3–98.2%, with a relative standard deviation of 1.2–4.2%. The results demonstrated that CD@MIP possessed the capability of specific adsorption and fluorescence detection of Png-Na, enabling simultaneous detection and enrichment of Png-Na in real samples.
- Subjects
IMPRINTED polymers; PENICILLIN G; DOPING agents (Chemistry); HIGH performance liquid chromatography; METHACRYLIC acid; ADSORPTION (Chemistry); ETHYLENE glycol; DOPING in sports
- Publication
Microchimica Acta, 2024, Vol 191, Issue 4, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-024-06269-5