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- Title
New two-dimensional nanocomposites combined with target-induced strategy in an electrochemical aptasensor for sensitive determination of sulfadimethoxine.
- Authors
Yan, Chuanyong; Mu, Zhaode; Wu, Yijie; Liao, Xingxing; Zhou, Jiaxu; Bai, Lijuan
- Abstract
Ni-Zn bimetallic organic framework nanosheets (NiZn-MOF NSs) were modified onto PEI-functionalized MXene for the first time. The combination of the two kinds of nanosheets forms a sensing platform with superior conductivity and biocompatibility. On this basis, a highly sensitive biosensor was developed for the determination of sulfadimethoxine (SDM). Furthermore, Au and Mn nanoparticles decorated reduced graphene oxide (Au-Mn/rGO) was introduced as a signal hindering molecule under the target-induced amplification strategy. When the Au-Mn/rGO-labelled SDM-binding aptamer (Au-Mn/rGO-SBA) specifically bound to target SDM, it detached from the electrode, thereby further amplifying the electrochemical signal of [Fe(CN)6]3−/4−. The developed aptasensor for SDM showed excellent response signals in the range 1 pg mL−1 to 100 ng mL−1, with a limit of detection (LOD) as low as 0.22 pg mL−1. Significantly, the proposed sensor also showed satisfactory results in milk samples with recoveries ranging from 87.0 to 96.4% and RSD from 1.5 to 5.1%, which is believed to be useful in food safety assays.
- Subjects
NANOCOMPOSITE materials; GOLD nanoparticles; GRAPHENE oxide; NANOSTRUCTURED materials; FOOD safety
- Publication
Microchimica Acta, 2023, Vol 190, Issue 11, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-023-06024-2