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- Title
Number of theoretical plates achievable by a toroidal capillary electrophoresis system.
- Authors
Kist, Tarso B. Ledur
- Abstract
The ability of a method and instrument to separate very similar compounds is related to the 'plate number,' a number indicating performance. The resolution between two neighboring peaks is proportional to the square root of the plate number. Currently available commercial capillary electrophoresis instruments easily reach plate numbers of a few million. In the present work, a capillary electrophoresis system with a toroidal platform is proposed and theoretically studied with the goal of extending the achievable plate number. In this new system, electrophoresis occurs in a nonstop continuous circulating mode within a closed loop capillary (toroid). Plate numbers upwards of one billion are theoretically predicted. This could resolve hundreds of unseparated mixtures of stereoisomers and other analytes that remain without a method for their analysis.
- Subjects
CAPILLARY electrophoresis; THEORETICAL plate number; CLOSED loop systems; MIXTURES; STEREOISOMERS
- Publication
Journal of Separation Science, 2017, Vol 40, Issue 23, p4619
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.201700712