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- Title
The enzymology of the human prostanoid pathway.
- Authors
Biringer, Roger Gregory
- Abstract
Prostanoids are short-lived autocrine and paracrine signaling molecules involved in a wide range of biological functions. They have been shown to be intimately involved in many different disease states when their regulation becomes dysfunctional. In order to fully understand the progression of any disease state or the biological functions of the well state, a complete evaluation of the genomics, proteomics, and metabolomics of the system is necessary. This review is focused on the enzymology for the enzymes involved in the synthesis of the prostanoids (prostaglandins, prostacyclins and thromboxanes). In particular, the isolation and purification of the enzymes, their enzymatic parameters and catalytic mechanisms are presented.
- Subjects
ENZYMOLOGY; DISEASE progression; PROSTANOIDS; PROTEOMICS
- Publication
Molecular Biology Reports, 2020, Vol 47, Issue 6, p4569
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-020-05526-z