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- Title
Kv11.1 channel subunit composition includes minK and varies developmentally in mouse cardiac muscle.
- Authors
Wang, Xun; Xu, Rongzuo; Abernathey, Grant; Taylor, Jordan; Alzghoul, M.B.; Hannon, Kevin; Hockerman, Gregory H.; Pond, Amber L.
- Abstract
The Kv11.1 (also ERG1) K+ channel underlies cardiac IKr, a current that contributes to repolarization in mammalian heart. In mice, IKr current density decreases with development and studies suggest that changes in the structure and/or properties of the heteromultimeric IKr/Kv11.1 channel are responsible. Here, using immunohistochemistry, we report that total Kv11.1 α subunit protein is more abundant in neonatal heart and is distributed throughout both adult and neonatal ventricles with greater abundance in epicardia. Immunoblots reveal that the α subunit alternative splice variant, Kv11.1a, is more abundant in adult heart while the Kv11.1b variant is more abundant in neonatal heart. Additionally, MinK channel subunit protein is shown to co-assemble with Kv11.1 protein and is more abundant in neonatal heart. In summary, Kv11.1/IKr channel composition varies developmentally and the higher IKr current density in neonatal heart is likely attributable to higher abundance of Kv11.1/IKr channels, more specifically, the Kv11.1b splice variant. Developmental Dynamics 237:2430-2437, 2008. © 2008 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2008, Vol 237, Issue 9, p2430
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.21671