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- Title
Efficient synthesis of [<sup>18</sup>F]FPyME: A new approach for the preparation of maleimide-containing prosthetic groups for the conjugation with thiols.
- Authors
Cavani, Melanie; Bier, Dirk; Holschbach, Marcus; Coenen, Heinz H.
- Abstract
An improved high yielding radiosynthesis of the known thiol-reactive maleimide-containing prosthetic group1-[3-(2-[18F]fluoropyridine-3-yloxy)propyl]pyrrole-2,5-dione ([18F]FPyME) is described. The target compound was obtained by a two-step one-pot procedure starting from a maleimide-containing nitro-precursor that was protected as a Diels-Alder adduct with 2,5-dimethylfurane. Nucleophilic radiofluorination followed by heat induced deprotection through a Retro Diels Alder reaction yielded, after chromatographic isolation, [18F]FPyME with a radiochemical yield of 20% in about 60 min overall synthesis time. A variety of other [18F]fluoropyridine based maleimide-containing prosthetic groups should be accessible via the described synthetic strategy.
- Subjects
MALEIMIDES; NUCLEOPHILIC substitution reactions; CHROMATOGRAPHIC analysis; THIOL synthesis; ELECTROPHILIC addition reactions
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2017, Vol 60, Issue 1, p87
- ISSN
0362-4803
- Publication type
Other
- DOI
10.1002/jlcr.3469