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- Title
Bactericidal Monoclonal Antibody Against Moraxella catarrhalis Lipooligosaccharide Cross-Reacts with Haemophilus Spp.
- Authors
Gergova, Raina T.; Iankov, Ianko D.; Haralambieva, Iana H.; Mitov, Ivan G.
- Abstract
Monoclonal antibodies (MAbs) against lipooligosaccharide (LOS) determinants after immunization of BALB/c mice with heat inactivated Moraxella catarrhalis serotype A were generated. MAb 219A9 was specific for a common epitope of A, B, and C M. catarrhalis serotypes in ELISA and immunofluorescent test (IFT). In both tests it also cross-reacted with whole bacteria and LPS antigens isolated from non-typeable H. influenzae and H. parainfluenzae strains. IgM antibody clone 219A9 possessed a strong bactericidal effect against the three serotypes in the presence of complement. Our results demonstrate that antibodies directed to a single LOS epitope common for A, B, and C serotype could be highly protective. This suggests that the common determinants are very promising in the development of LOS-based vaccine against M. catarrhalis. The cross-reactions of MAb 219A9 with Haemophilus spp. also show that immunization could result in immune response to epitopes conserved in other important respiratory pathogens.
- Subjects
MORAXELLA; MONOCLONAL antibodies; ANTIGENS; HAEMOPHILUS influenzae; HAEMOPHILUS parainfluenzae
- Publication
Current Microbiology, 2007, Vol 54, Issue 2, p85
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-005-0463-6