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- Title
Three dimensional printed bioglass/gelatin/alginate composite scaffolds with promoted mechanical strength, biomineralization, cell responses and osteogenesis.
- Authors
Ye, Qing; Zhang, Ying; Dai, Kun; Chen, Xiaofeng; Read, Hannah Mae; Zeng, Lei; Hang, Fei
- Abstract
In this study, porous bioglass/gelatin/alginate bone tissue engineering scaffolds were fabricated by three-dimensional printing. The compressive strength and in vitro biomineralization properties of the bioglass–gelatin–alginate scaffolds (BG/Gel/SA scaffolds) were significantly improved with the increase of bioglass content until 30% weight percentage followed by a rapid decline in strength. In addition, the cells attach and spread on the BG/Gel/SA scaffolds surfaces represents good adhesion and biocompatibility. Furthermore, the cells (rat bone marrow mesenchymal stem cells, mBMSCs) proliferation and osteogenic differentiation on the BG/Gel/SA scaffolds were also promoted with the increase of bioglass content. Overall, the adding of bioglass in Gel/SA scaffolds promotes mechanical strength and in vitro osteogenic properties and the 30 BG scaffold (30%wt BG) has potential applications in bone tissue engineering and bone regenerative repair because of good compressive strength, biocompatibility, and in vitro osteogenesis.
- Subjects
BIOACTIVE glasses; BONE growth; TISSUE scaffolds; BIOMINERALIZATION; GELATIN; MESENCHYMAL stem cells; TISSUE engineering; THREE-dimensional printing
- Publication
Journal of Materials Science: Materials in Medicine, 2020, Vol 31, Issue 9, pN.PAG
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-020-06413-6