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- Title
Preparation and blood coagulation evaluation of chitosan microspheres.
- Authors
Qi Zhao Wang; Xi Guang Chen; Zi Xiang Li; Wang, Song; Cheng Sheng Liu; Xiang Hong Meng; Chen Guang Liu; Ying Hui Lv; Le Jun Yu
- Abstract
Cross-linked chitosan microspheres (40–100 μm) with smooth surface were prepared by the methods of emulsification and ethanol coagulant. FTIR results showed that the cross-linking reaction occurred on the amino groups of chitosan molecules. The swelling characteristic of chitosan microspheres was influenced by the environment pH, being generally greater at low rather than higher pH values. The coagulation properties of chitosan microspheres were evaluated by dynamic blood clotting, platelet adhesion and activation, erythrocyte adhesion, hemolysis, and protein absorption assays. Chitosan microspheres can shorten the clotting time and induce the adhesion and activation of platelets. But the shortening of clotting time by chitosan microspheres may be related to not only platelet aggregation, but also erythrocyte aggregation. Take together, chitosan microspheres may be potential use as thrombospheres.
- Subjects
BLOOD coagulation; CHITOSAN; MICROSPHERES; HYDROGEN-ion concentration; ERYTHROCYTES; BLOOD platelets
- Publication
Journal of Materials Science: Materials in Medicine, 2008, Vol 19, Issue 3, p1371
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-007-3243-y