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- Title
Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cells.
- Authors
Abe, Takumi; Itoh, Tomoki; Terasaki, Masaru
- Abstract
A concise synthesis of pyrano[3,2‐e]indole alkaloid fontanesine B by a Fischer indolization is described. This key Fischer indolization starts with the pyran‐ring and alkene intact, facilitating potential synthetic applications. Furthermore, fontanesine B and its isomer were evaluated for in vitro antiproliferative activity against human colorectal cancer cells. The isomer of fontanesine B showed higher antiproliferative activity than the natural product, fontanesine B (2).
- Subjects
COLORECTAL cancer; CANCER cells; INDOLE alkaloids; ISOMERS; NATURAL products; INDOLE
- Publication
Helvetica Chimica Acta, 2019, Vol 102, Issue 7, pN.PAG
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201900116