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- Title
Waterborne Risperidone Decreases Stress Response in Zebrafish.
- Authors
Idalencio, Renan; Kalichak, Fabiana; Rosa, João Gabriel Santos; Oliveira, Tiago Acosta de; Koakoski, Gessi; Gusso, Darlan; Abreu, Murilo Sander de; Giacomini, Ana Cristina Varrone; Barcellos, Heloísa Helena de Alcântara; Piato, Angelo L.; Barcellos, Leonardo José Gil
- Abstract
The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.
- Subjects
PSYCHOLOGICAL stress; RISPERIDONE; ZEBRA danio; METABOLITES; NEUROENDOCRINOLOGY; TRANQUILIZING drugs; BEHAVIOR; THERAPEUTICS
- Publication
PLoS ONE, 2015, Vol 10, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0140800