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- Title
A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking.
- Authors
Le Daré, Brendan; Allard, Sophie; Bouvet, Renaud; Baert, Alain; Allard, Pierre-Marie; Morel, Isabelle; Gicquel, Thomas
- Abstract
Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Toxicological analyses of post-mortem samples (using a liquid chromatography high-resolution mass spectrometry (LC-HR-MS) method) highlighted high concentrations of acebutolol and its metabolite diacetolol in femoral blood (92.8 mg/L and 21.2 mg/L, respectively) and other matrices (cardiac blood, urine, bile, and gastric contents). A molecular networking approach provided useful information on acebutolol's metabolism and revealed the existence of an unknown phase II metabolite of acebutolol. Molecular networking also facilitated visualization of the complex LC-HR-MS/MS datasets and the sample-to-sample comparisons that confirmed massive acebutolol intoxication by ingestion.
- Subjects
BILE; POISONING; ADRENERGIC receptors; ANGINA pectoris; MASS spectrometry; SELF-poisoning
- Publication
International Journal of Legal Medicine, 2020, Vol 134, Issue 1, p251
- ISSN
0937-9827
- Publication type
Article
- DOI
10.1007/s00414-019-02062-9