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- Title
The dynamic nuclear periphery as a facilitator of gamete health and rejuvenation.
- Authors
King, Grant A.; Ünal, Elçin
- Abstract
The nuclear periphery is a hotspot for the accumulation of age-induced damage in eukaryotic cells. The types of damage that occur at the periphery and their phenotypic consequences have begun to be characterized; however, the mechanisms by which cells repair or eliminate nuclear damage remain poorly understood. Using budding yeast meiosis as a natural system to study cellular rejuvenation, we recently discovered a novel nuclear quality control event, in which age-induced damage is sequestered away from dividing chromosomes to a discarded nuclear compartment that we term the GUNC (for "Gametogenesis Uninherited Nuclear Compartment"). Interestingly, extensive nuclear remodeling occurs even in young cells, including a surprising modularity of the nuclear pore complex, suggesting a general contribution to gamete fitness. In this review, we discuss these findings in the context of recent evidence that the nuclear periphery is a highly dynamic region critical for cellular health.
- Subjects
EUKARYOTIC cells; GAMETES; GAMETOGENESIS; QUALITY control
- Publication
Current Genetics, 2020, Vol 66, Issue 3, p487
- ISSN
0172-8083
- Publication type
Article
- DOI
10.1007/s00294-019-01050-1