We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacotherapy of Gastrointestinal Tract Injuries Caused by Radioactive Particles in Animals.
- Authors
Budarkov, V. A.; Zenkin, A. S.; Grekhova, N. V.; Kozmin, G. V.
- Abstract
The gastrointestinal tract (GIT) is the main critical organ during internal exposure of the body to radioactive particles (RPs). We performed an experimental study of the therapy for acute local injuries in the form of ulcerative gastroenteritis caused by irradiation of animals with artificial highly active RPs. The etiological factor was β-radiation emitted by 165Dy (42%), 142Pr (45%), and 90Y (13%) or 235U fission products caused by thermal neutrons, simulating the radioactive decay of 10-hour-old nuclear fission products. Study of the specific activity of various chemical or biological substances was carried out on Wistar rats, outbred guinea pigs, and Prekos sheep. Radioactive particles were suspended by sparging in a 2.5% potato starch gel and injected into rodents intragastrically through a metal probe using a syringe. In experiments with sheep, RPs were given to animals with food. The efficacy of drugs for treatment of radiation injury with different mechanisms of action was tested: (i) drugs that increase natural resistance, (ii) drugs that have a local wound-healing effect, (iii) a saline laxative, and (iv) cholinomimetics. To evaluate the efficiency of treatment for radiation gastroenterocolitis, clinical and morphological parameters as well as survival rates were used. Good therapeutic efficacy of Glauber's salt, vinylin, carbacholinum, and pilocarpine, in combination with dimethyl sulfoxide and prodigiosan in combination with carbacholinum and bicillin-5, was found. It was manifested by a significant decrease in the intensity of injury to the gastrointestinal mucosa, accelerated healing of radiation ulcers, and an increase in the survival rate of animals. Our results indicate the importance of further investigation of the treatments of local radiation injuries to the gastrointestinal tract caused by RPs, using new formulations, as well as complex application of pharmacological agents.
- Subjects
FISSION products; SODIUM sulfate; RADIATION injuries; GASTROINTESTINAL mucosa; DRUG therapy; AMYLOPLASTS; GASTROINTESTINAL system
- Publication
Biology Bulletin, 2022, Vol 49, Issue 11, p2065
- ISSN
1062-3590
- Publication type
Article
- DOI
10.1134/S1062359022110036