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- Title
PHYSICOCHEMICAL PROPERTIES AND PHARMACOLOGY OF AMLODIPINE BESYLATE: A BRIEF REVIEW.
- Authors
Ahsan, Syed Furqan; Khan, Marium Fatima
- Abstract
Hypertension is one of the well-studied risk factors for cardiovascular diseases and the oldest class of hypertensive drugs is the calcium channel blockers. Amlodipine besylate (ADB) belongs to the dihydropyridine family and is known as an effective initial treatment for hypertension and angina. It has a gradual onset of action and is administered in concomitant diseases with minimal side effects. Its basic mechanism of action is the blockage of calcium ions influx into cardiac muscles and vascular muscles. The physical appearance of ADB is white crystalline with a molecular weight of 567.1. Its 6.9 mg is equivalent to 5 mg of amlodipine (AM) free base. This review focuses on all the basic aspects of ADB which is one of the initial treatment regimens for cardiovascular diseases since last two decades.
- Subjects
HYPERTENSION; CARDIOVASCULAR diseases; CALCIUM antagonists; ANTIHYPERTENSIVE agents; BLOOD pressure
- Publication
Baqai Journal of Health Sciences, 2017, Vol 20, Issue 2, p27
- ISSN
2312-4423
- Publication type
Article