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- Title
Long-Term Outcomes of Sentinel Lymph Node Biopsy for Ductal Carcinoma in Situ.
- Authors
Hung, Peiyin; Wang, Shi-Yi; Killelea, Brigid K; Mougalian, Sarah S; Evans, Suzanne B; Sedghi, Tannaz; Gross, Cary P
- Abstract
The use of sentinel lymph node biopsy (SLNB) for ductal carcinoma in situ (DCIS) is controversial. Using population-cohort data, we examined whether SLNB improves long-term outcomes among patients with DCIS who underwent breast-conserving surgery. We identified 12 776 women aged 67–94 years diagnosed during 2001–2013 with DCIS who underwent breast-conserving surgery from the US Surveillance, Epidemiology, and End Results-Medicare dataset, 1992 (15.6%) of whom underwent SLNB (median follow-up: 69 months). Tests of statistical significance are two-sided. Patients with and without SLNB did not differ statistically significantly regarding treated recurrence (3.9% vs 3.7%; P =.62), ipsilateral invasive occurrence (1.4% vs 1.7%, P =.33), or breast cancer mortality (1.0% vs 0.9%, P =.86). With Mahalanobis-matching and competing-risks survival analyses, SLNB was not statistically significantly associated with treated recurrence, ipsilateral invasive occurrence, or breast cancer mortality (P ≥ .27). Our findings do not support the routine performance of SLNB for older patients with DCIS amenable to breast conservation.
- Subjects
SENTINEL lymph nodes; BIOPSY; BREAST cancer
- Publication
JNCI Cancer Spectrum, 2019, Vol 3, Issue 4, pN.PAG
- ISSN
2515-5091
- Publication type
Article
- DOI
10.1093/jncics/pkz052