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- Title
RE: Heterozygous BRCA1 and BRCA2 and mismatch repair gene pathogenic variants in children and adolescents with cancer.
- Authors
Li, Shuai; Nguyen-Dumont, Tu; Southey, Melissa C; Hopper, John L
- Abstract
Kratz and colleagues ([1]) asked if pathogenic variants (PVs) in adult cancer predisposition genes are associated with the risk of childhood and adolescent cancers. We found that, for PVs in breast cancer susceptibility genes, using older control participants with an age adjustment gave breast cancer risk estimates consistent with those estimated using age-matched control participants ([6]).
- Subjects
DNA mismatch repair; GENETIC variation; CHILDHOOD cancer; BRCA genes
- Publication
JNCI: Journal of the National Cancer Institute, 2023, Vol 115, Issue 6, p757
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djad056