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- Title
Decoding Tumor Angiogenesis for Therapeutic Advancements: Mechanistic Insights.
- Authors
Kaur, Geetika; Roy, Bipradas
- Abstract
Tumor angiogenesis, the formation of new blood vessels within the tumor microenvironment, is considered a hallmark of cancer progression and represents a crucial target for therapeutic intervention. The tumor microenvironment is characterized by a complex interplay between proangiogenic and antiangiogenic factors, regulating the vascularization necessary for tumor growth and metastasis. The study of angiogenesis involves a spectrum of techniques, spanning from biomarker assessment to advanced imaging modalities. This comprehensive review aims to provide insights into the molecular intricacies, regulatory dynamics, and clinical implications of tumor angiogenesis. By delving into these aspects, we gain a deeper understanding of the processes driving vascularization in tumors, paving the way for the development of novel and effective antiangiogenic therapies in the fight against cancer.
- Subjects
NEOVASCULARIZATION; TUMOR growth; VASCULAR endothelial growth factors; PLATELET-derived growth factor; FIBROBLAST growth factors
- Publication
Biomedicines, 2024, Vol 12, Issue 4, p827
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines12040827