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- Title
FUNCTIONALIZED CARBON NANOSTRUCTURES AS TEMOZOLOMIDE CARRIERS: PHYSICOCHEMICAL AND BIOPHARMACEUTICAL CHARACTERIZATION.
- Authors
MILENKOVSKA, RADMILA; GESKOVSKI, NIKOLA; MAKRESKI, PETRE; GROZDANOV, ANITA; POPOVSKI, EMIL; PETRUSHEVSKI, GJORGJI; CRCAREVSKA, MAJA SIMONOSKA; MLADENOVSKA, KRISTINA
- Abstract
In this study, temozolomide (TMZ), a drug used in the treatment of anaplastic astrocytoma and glioblastoma multiforme, was incorporated in multiwalled carbon nanotubes (MWCNTs) and hybrid carbon nanotubes with graphene (MWCNTs-G) functionalized by polyethylene glycol (PEG). The aim was to evaluate the potential of these nanocarriers for targeted delivery and sustained release of TMZ in brain tumor cells. Oxidized MWCNTs and MWCNTs-G were noncovalently functionalized with PEGs of different molecular weights and subsequently loaded with TMZ following standard procedures. Thorough physicochemical and biopharmaceutical characterization of the TMZ-loaded carbon nanocarriers pointed to high encapsulation efficacy (up to 67%) and drug loading (up to 18% out of 25% theoretical value) and homogeneous particle size distribution, with zaverage (160 to 300 nm) and zeta potential (-31 to -21 mV) of the particles adequate for crossing the blood-brain-tumor-barrier (BBTB) and entering into the tumor cells. Successful functionalization and TMZ loading were confirmed by SEM and TEM images, UV-Vis absorption, infrared and Raman spectroscopy, and TGA analyses. Sustained release of TMZ from the carbon nanocarriers was observed in vitro. The presented findings form a fundamental platform for further investigation of these formulations against different types of glioma cells and in adequate animal models.
- Subjects
MULTIWALLED carbon nanotubes; TEMOZOLOMIDE; ZETA potential; PARTICLE size distribution; POLYMERSOMES; NANOSTRUCTURES; GLIOBLASTOMA multiforme; BLOOD viscosity
- Publication
Chemical Industry & Chemical Engineering Quarterly, 2024, Vol 30, Issue 3, p243
- ISSN
1451-9372
- Publication type
Article
- DOI
10.2298/CICEQ230505027M