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- Title
Using HScore for Evaluation of Hemophagocytosis in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children.
- Authors
Avrusin, Ilia S.; Abramova, Natalia N.; Belozerov, Konstantin E.; Bregel, Liudmila V.; Efremova, Olesya S.; Vilnits, Alla A.; Konstantinova, Julia E.; Isupova, Eugenia A.; Kornishina, Tatiana L.; Masalova, Vera V.; Kalashnikova, Olga V.; Chasnyk, Vyacheslav G.; Aleksandrovich, Yuriy S.; Ivanov, Dmitri O.; Kostik, Mikhail M.
- Abstract
Hemophagocytic syndrome is a key point in the pathogenesis of severe forms of multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C). The factors associated with hemophagocytosis in patients with MIS-C were assessed in the present study of 94 boys and 64 girls ranging in age from 4 months to 17 years, each of whose HScore was calculated. In accordance with a previous analysis, patients with HScore ≤ 91 (n = 79) and HScore > 91 (n = 79) were compared. Patients with HScore > 91 had a higher frequency of symptoms such as cervical lymphadenopathy, dry cracked lips, bright mucous, erythema/swelling of hands and feet, peeling of fingers, edematous syndrome, hepatomegaly, splenomegaly, and hypotension/shock. They also had a higher erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and D-dimer levels, and a tendency to anemia, thrombocytopenia, and hypofibrinogenemia. They more often needed acetylsalicylic acid and biological treatment and were admitted to ICU in 70.9% of cases. Conclusion: The following signs of severe MIS-C were associated with HScore > 91: myocardial involvement, pericarditis, hypotension/shock, and ICU admission.
- Subjects
MULTISYSTEM inflammatory syndrome; BLOOD sedimentation; MULTISYSTEM inflammatory syndrome in children; ASPIRIN; COVID-19; HAND-foot syndrome; MYELOFIBROSIS
- Publication
Biomedicines, 2024, Vol 12, Issue 2, p294
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines12020294