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- Title
Association between Immunophenotypic Parameters and Molecular Alterations in Acute Myeloid Leukemia.
- Authors
Pessoa, Flávia Melo Cunha de Pinho; Machado, Caio Bezerra; Barreto, Igor Valentim; Sampaio, Giulia Freire; Oliveira, Deivide de Sousa; Ribeiro, Rodrigo Monteiro; Lopes, Germison Silva; de Moraes, Maria Elisabete Amaral; de Moraes Filho, Manoel Odorico; de Souza, Lucas Eduardo Botelho; Khayat, André Salim; Moreira-Nunes, Caroline Aquino
- Abstract
Acute myeloid leukemia (AML) is a hematologic malignancy that occurs due to alterations such as genetic mutations, chromosomal translocations, or changes in molecular levels. These alterations can accumulate in stem cells and hematopoietic progenitors, leading to the development of AML, which has a prevalence of 80% of acute leukemias in the adult population. Recurrent cytogenetic abnormalities, in addition to mediating leukemogenesis onset, participate in its evolution and can be used as established diagnostic and prognostic markers. Most of these mutations confer resistance to the traditionally used treatments and, therefore, the aberrant protein products are also considered therapeutic targets. The surface antigens of a cell are characterized through immunophenotyping, which has the ability to identify and differentiate the degrees of maturation and the lineage of the target cell, whether benign or malignant. With this, we seek to establish a relationship according to the molecular aberrations and immunophenotypic alterations that cells with AML present.
- Subjects
ACUTE myeloid leukemia; CELL surface antigens; ACUTE leukemia; HEMATOLOGIC malignancies; HEMATOPOIETIC stem cells; PRELEUKEMIA
- Publication
Biomedicines, 2023, Vol 11, Issue 4, p1098
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11041098