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- Title
Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort.
- Authors
Pinto, Pedro Caetano; Rönnau, Cindy; Burchardt, Martin; Wolff, Ingmar
- Abstract
Kidney cancer and chronic kidney disease are two renal pathologies with very different clinical management strategies and therapeutical options. Nonetheless, the cellular and molecular mechanisms underlying both conditions are closely related. Renal physiology is adapted to operate with a limited oxygen supply, making the kidney remarkably equipped to respond to hypoxia. This tightly regulated response mechanism is at the heart of kidney cancer, leading to the onset of malignant cellular phenotypes. Although elusive, the role of hypoxia in chronic kidney diseases is emerging as related to fibrosis, a pivotal factor in decaying renal function. The present review offers a perspective on the common biological traits shared between kidney cancer and chronic kidney disease and the available and prospective therapies for both conditions.
- Subjects
RENAL cancer; CHRONIC kidney failure; KIDNEY diseases; KIDNEY physiology
- Publication
Biomedicines, 2021, Vol 9, Issue 12, p1761
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines9121761