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- Title
Long-acting Injectable PrEP Interest and General PrEP Awareness among People who Inject Drugs in the San Diego-Tijuana Border Metroplex.
- Authors
Eger, William H.; Bazzi, Angela R.; Valasek, Chad J.; Vera, Carlos F.; Harvey-Vera, Alicia; Artamonova, Irina; Rangel, M Gudelia; Strathdee, Steffanie A.; Pines, Heather A.
- Abstract
Long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) could help overcome multilevel challenges to HIV prevention for people who inject drugs (PWID), including those in the binational San Diego-Tijuana metroplex. Yet, general PrEP awareness and interest in LAI-PrEP remain underexplored among PWID. From 2020 to 2021, 562 HIV-negative PWID in San Diego and Tijuana completed surveys assessing general PrEP awareness and interest in oral and LAI-PrEP. Modified Poisson regression examined factors associated with general PrEP awareness. Multinomial logistic regression assessed factors associated with interest in both oral and LAI-PrEP, oral PrEP only, LAI-PrEP only, or neither. General PrEP awareness was low (18%) and associated with experiencing unsheltered homelessness (adjusted prevalence ratio [APR] = 1.50, 95% confidence interval [CI]: 0.96–2.33), past 6-month fentanyl injection (APR = 1.53, 95% CI: 1.04–2.25), and transactional sex (APR = 1.71, 95% CI: 1.06–2.76). Interest in oral PrEP only was most common (44%), followed by LAI-PrEP only (25%) and neither (16%). Compared to the odds of being interested in LAI-PrEP only, the odds of being interested in oral PrEP only were lower among those who were stopped by police (AOR = 0.38, 95% CI: 0.22–0.65), reported past 6-month fentanyl injection (AOR = 0.33, 95% CI: 0.20–0.56), polydrug use (AOR = 0.48, 95% CI: 0.27–0.86), injecting multiple times daily (AOR = 0.26, 95% CI: 0.14–0.46), receptive syringe use (AOR = 0.30, 95% CI: 0.19–0.49), and higher perceived HIV risk (AOR = 0.24, 95% CI: 0.15–0.39). Interest in LAI-PrEP was more common among PWID reporting social and structural factors that could interfere with oral PrEP adherence, suggesting LAI-PrEP implementation could increase PrEP coverage among those most vulnerable to HIV.
- Subjects
MEXICO; CALIFORNIA; HIV infection risk factors; HIV infection transmission; HIV prevention; HEALTH literacy; POISSON distribution; SCALE analysis (Psychology); SUBSTANCE abuse; CONTROLLED release preparations; RESEARCH funding; MULTIPLE regression analysis; NEEDLE sharing; HUMAN sexuality; QUESTIONNAIRES; DESCRIPTIVE statistics; PRE-exposure prophylaxis; ODDS ratio; INJECTIONS; ATTITUDE (Psychology); SEX customs; CONFIDENCE intervals; HOMELESSNESS; POLICE; RISK perception; DISEASE susceptibility; DATA analysis software; ALCOHOLISM; INTRAVENOUS drug abusers; PSYCHOSOCIAL factors; FENTANYL; TRANSACTIONAL sex; SELF-perception
- Publication
AIDS & Behavior, 2024, Vol 28, Issue 5, p1650
- ISSN
1090-7165
- Publication type
Article
- DOI
10.1007/s10461-024-04285-3