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- Title
Design and synthesis of imidazo[4,5- c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors.
- Authors
Lomov, D.; Lyashchuk, S.; Abramyants, M.
- Abstract
Computer simulation at the PM7 level of theory of the structures of imidazo[4,5- c]pyridine derivatives (deaza analogs of purines) and their complexes with Aurora kinase A (AURKA) indicated prospects for their use as potential AURKA inhibitors in the treatment of oncological diseases. A number of new compounds of the selected imidazo[4,5- c]pyridine series, for which the highest inhibitory activity against AURKA was predicted, were synthesized in high yields for further biological testing.
- Subjects
IMIDAZOPYRIDINES; IMIDAZOLES; CHEMICAL synthesis; AURORA kinases; PYRIDINE derivatives; CANCER treatment
- Publication
Russian Journal of Organic Chemistry, 2016, Vol 52, Issue 12, p1822
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428016120198