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- Title
Synthesis of 4-trifluoromethyl-3,4-dihydro-1,3,5-triazino[2,1- a]isoindol-2-ones by cyclocondensation of 1-aryl-1-chloro-2,2,2-trifluoroethyl isocyanates with 3-amino-1-arylimino-1 H-isoindoles.
- Authors
Biitseva, A.; Gordienko, O.; Kornilov, M.; Sukach, V.; Vovk, M.; Shishkin, O.; D’yakonenko, V.
- Abstract
4-Trifluoromethyl-3,4-dihydro-1,3,5-triazino[2,1- a]isoindol-2-ones were prepared by reaction of 1-aryl-1-chloro-2,2,2-trifluoroethyl isocyanates with 3-amino-1-arylimino-1 H-isoindoles in the presence of triethylamine. In some events alongside the main product isomeric 2-trifluoromethyl-2,3-dihydro-1,3,5-triazino[2,1-a]isoindol-4-ones were obtained. The regioselectivity of the reaction is affected by sterical and electronic characteristics of substituents and by temperature.
- Subjects
TRIFLUOROIODOMETHANE; ISOINDOLE; CONDENSATION products (Chemistry); AROMATIC amines; ISOCYANATES; ETHYLAMINES
- Publication
Russian Journal of Organic Chemistry, 2007, Vol 43, Issue 2, p263
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428007020182