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- Title
Dose assessment of 2% chlorhexidine acetate for canine superficial pyoderma.
- Authors
Murayama, Nobuo; Terada, Yuri; Okuaki, Mio; Nagata, Masahiko
- Abstract
The dose of 2% chlorhexidine acetate (2CA; Nolvasan® Surgical Scrub; Fort Dodge Animal Health, Fort Dodge, IA, USA) for canine superficial pyoderma was evaluated. The first trial compared three doses (group 1, 57 mL/m2 body surface area; group 2, 29 mL/m2 body surface area; and group 3, 19 mL/m2 body surface area) in a randomized, double-blind, controlled fashion. Twenty-seven dogs with superficial pyoderma were treated with 2CA at the allocated doses every 2 days for 1 week. The owners and investigators subjectively evaluated the dogs, and investigators scored skin lesions, including erythema, papules/pustules, alopecia and scales, on a 0-4 scale. There were no significant differences in response between the treatment groups. The second trial established a practical dose-measuring method for 2CA. Sixty-eight owners were asked to apply 2CA on their palm in an amount corresponding to a Japanese ¥500 coin, 26.5 mm in diameter. This yielded an average dose of 0.90 ± 0.40 mL. Mathematically, the doses used in groups 1, 2 and 3 can be represented as one coin per approximately one-, two- and three-hand-sized lesions, respectively. The results therefore suggest that owners instructed to apply one coin of the product per two-hand-sized areas of superficial pyoderma would use the range of doses evaluated in this trial.
- Subjects
CHLORHEXIDINE; ACETATES; SUPERFICIALITY; PYODERMA in animals; FORT Dodge Animal Health Ltd.; DRUG dosage; ERYTHEMA; BALDNESS in animals; VETERINARY therapeutics
- Publication
Veterinary Dermatology, 2011, Vol 22, Issue 5, p449
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/j.1365-3164.2011.00968.x