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- Title
Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults.
- Authors
Min, Jungwon; Rouanet, Jeremy; Martini, Alessandra Cadete; Nashiro, Kaoru; Yoo, Hyun Joo; Porat, Shai; Cho, Christine; Wan, Junxiang; Cole, Steve W.; Head, Elizabeth; Nation, Daniel A.; Thayer, Julian F.; Mather, Mara
- Abstract
Slow paced breathing via heart rate variability (HRV) biofeedback stimulates vagus-nerve pathways that counter noradrenergic stress and arousal pathways that can influence production and clearance of Alzheimer's disease (AD)-related proteins. Thus, we examined whether HRV biofeedback intervention affects plasma Αβ40, Αβ42, total tau (tTau), and phosphorylated tau-181 (pTau-181) levels. We randomized healthy adults (N = 108) to use slow-paced breathing with HRV biofeedback to increase heart rate oscillations (Osc+) or to use personalized strategies with HRV biofeedback to decrease heart rate oscillations (Osc−). They practiced 20–40 min daily. Four weeks of practicing the Osc+ and Osc− conditions produced large effect size differences in change in plasma Aβ40 and Aβ42 levels. The Osc+ condition decreased plasma Αβ while the Osc− condition increased Αβ. Decreases in Αβ were associated with decreases in gene transcription indicators of β-adrenergic signaling, linking effects to the noradrenergic system. There were also opposing effects of the Osc+ and Osc− interventions on tTau for younger adults and pTau-181 for older adults. These results provide novel data supporting a causal role of autonomic activity in modulating plasma AD-related biomarkers. Trial registration: NCT03458910 (ClinicalTrials.gov); first posted on 03/08/2018.
- Subjects
OLDER people; HEART beat; PLASMA oscillations; TAU proteins; AMYLOID; BIOFEEDBACK training; BETA adrenoceptors; TRANSCRANIAL alternating current stimulation
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-30167-0