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- Title
Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis.
- Authors
Jiaqian Zhang; Hongjiang Liu; Yuehong Chen; Huan Liu; Shengxiao Zhang; Geng Yin; Qibing Xie
- Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent studies found the absolute and relative decreases in circulating regulatory T cells (Tregs) in RA patients. Tregs are a unique type of cells exhibiting immunosuppressive functions, known for expressing the Foxp3 gene. They are instrumental in maintaining immunological tolerance and preventing autoimmunity. Increasing the absolute number and/or enhancing the function of Tregs are effective strategies for treating RA. This article reviews the studies on the mechanisms and targeted therapies related to Tregs in RA, with a view to provide better ideas for the treatment of RA.
- Subjects
REGULATORY T cells; RHEUMATOID arthritis; IMMUNOLOGICAL tolerance; ARTICULAR cartilage; BONE resorption
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1312919