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- Title
Modelling the association between biomarkers and clinical outcome: An introduction to nonlinear joint models.
- Authors
Kerioui, Marion; Bertrand, Julie; Bruno, René; Mercier, François; Guedj, Jérémie; Desmée, Solène
- Abstract
Nonlinear joint models are a powerful tool to precisely analyse the association between a nonlinear biomarker and a time‐to‐event process, such as death. Here, we review the main methodological techniques required to build these models and to make inferences and predictions. We describe the main clinical applications and discuss the future developments of such models.
- Subjects
TREATMENT effectiveness; BIOMARKERS; CLINICAL medicine
- Publication
British Journal of Clinical Pharmacology, 2022, Vol 88, Issue 4, p1452
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1111/bcp.15200