We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat.
- Authors
Grueneberger, Jodok Matthias; Fritz, Tobias; Cheng Zhou; Meyer, Sebastian; Karcz-Socha, Iwona; Sawczyn, Tomasz; Stygar, Dominica; Goos, Matthias; Hopt, Ulrich Theodor; Küsters, Simon
- Abstract
Introduction: Fast delivery of food to the terminal ileum is thought to be pathophysiologically responsible for type 2 diabetes remission after obesity surgery. Imitating this effect, ileal transposition (IT) is designed as initiating diabetes remission for non-obese patients. Aim: To date, it is not clear which length of the transposed segment achieves the best glucose lowering results. As previous rodent data mostly rely on a 10 cm IT, the current study evaluated a long segment IT (20 cm) in the diabetic obese Zucker rat. Material and methods: Twenty male diabetic obese Zucker rats (Crl:ZUC-Leprfa) were randomly assigned to undergo either a long segment (20 cm; ~ 50% of ileum) IT or sham surgery. Glucose control was determined by an oral glucose tolerance test (OGTT) on day -7, 0,14 and 20. Analysis of the incretin hormones glucagon-like peptide 1 (GLP-1), pep-tide YY (PYY) and insulin was included in the first and third OGTT. Results: Ileal transposition animals showed an early improvement of glucose control after 14 days (area under the curve: IT vs. baseline 314.7 ±229.0 mmol/l x min vs. 564.6 ± 268.5 mmol/l x min; p < 0.05). Compared to sham animals, glucose-stimulated GLP-1 and PYY levels were raised (5.75 ± 3.73 pmol/l vs. 18.52 ± 14.22 pmol/l, p < 0.05; 129.7±64.62 pmol/l vs. 164.0 ± 62.26 pmol/l, p < 0.05). Body weight gain from postoperative day 5 was greater for sham animals (50.22 ±20.93 g vs. 16.4 ± 25.93 g; p < 0.01). Conclusions: Long segment IT shows a rapid rise in GLP-1 and PYY levels, thus leading to early amelioration of glucose control.
- Subjects
TYPE 2 diabetes treatment; BLOOD sugar measurement; BARIATRIC surgery; METABOLIC regulation; ZUCKER rats; GLUCOSE tolerance tests
- Publication
Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i Inne Techniki Mało Inwazyjne, 2013, Vol 2013, Issue 2, p130
- ISSN
1895-4588
- Publication type
Article
- DOI
10.5114/wiitm.2011.32925