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- Title
Low frequency of skin cancers in vitiligo patients.
- Authors
Algiert, Barbara; Erkiert-Polguj, Anna; Dana, Agnieszka; Czubiński, Dariusz; Rotsztejn, Helena
- Abstract
Vitiligo is a disease characterized by discoloration of the skin and hair as a result of damage of melanocytes. The exact mechanism of the disease is still unknown. Theories about the pathogenesis focus on autoimmune, neurogenic and autocytotoxic mechanisms. There is a decreased risk of incidence of skin cancers in patients with vitiligo. The relation between vitiligo and decreased frequency of cases of malignant melanoma (MM) may be a consequence of the immune response to antigens, which are common for melanocytes and MM cells. Genetic studies indicate a mutually exclusive relationship of melanoma and vitiligo. This disease is also associated with a polymorphism in the TYR gene which encodes tyrosinase. Studies also indicate a decreased risk of incidence of nonmelanoma skin cancers (NMSC) in patients with vitiligo.
- Subjects
RISK factors of skin cancer; MELANOCYTES; VITILIGO; CYTOTOXINS; AUTOIMMUNE diseases
- Publication
Dermatology Review / Przeglad Dermatologiczny, 2016, Vol 103, Issue 6, p486
- ISSN
0033-2526
- Publication type
Article
- DOI
10.5114/dr.2016.63840