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- Title
Successful unrelated cord blood transplantation in two children with severe combined immunodeficiency syndrome.
- Authors
Fagioli, F; Biasin, E; Berger, M; Nesi, F; Saroglia, E H; Miniero, R; Martino, S; Tovo, P A
- Abstract
We describe the successful unrelated cord blood transplantation in two patients affected by a Zap-70 deficiency and an Omenn-like syndrome, respectively. The patients were hospitalised for recurrent infections at the age of 13 and 2 months, respectively. An unrelated cord blood unit was found for each. The conditioning regimen was cyclophosphamide, busulfan and antithymocyte globulin. The total number of infused cells was 15.1x107/kg and 17x107/kg, respectively. Neutrophil engraftment was achieved on days +15 and +23, and platelet count >50x109/l was achieved on days +21 and +52, respectively. One patient presented acute Graft-versus-host disease (GVHD) grade I and the other grade III. Chimerism was mixed and full donor. Normal lymphoproliferative response to mitogens and alloantigens was detectable at 6 months for both. No chronic GVHD was observed in either. The patients are alive and well at 53 and 15 months after transplantation. In conclusion, umbilical cord blood represents a valid alternative source of haemopoietic stem cells.Bone Marrow Transplantation (2003) 31, 133-136. doi:10.1038/sj.bmt.1703800
- Subjects
CORD blood; TRANSPLANTATION of organs, tissues, etc.; IMMUNODEFICIENCY; JUVENILE diseases
- Publication
Bone Marrow Transplantation, 2003, Vol 31, Issue 2, p133
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1703800